Correlation between Interleukin-17 Levels with C-Reactive Protein and Neutrophil Lymphocyte Ratio in Sepsis

Background: Sepsis is a condition in systemic infection associated with organdysfunction. Interleukin-17 pro-inflammatory cytokine produced by Th-17 cells. C-reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used asmarkers of inflammation. The relationship between IL-17 as proinflammatorycytokine CRP NLR has not reported.Objective: This study aims to prove the correlation NLRin septic patients.Methods: Analytical observational cross-sectional approach was carriedout on 40 patients July–December 2020. levels were obtained theELISA method while using immunoturbidimetric method.NLR result dividing absolute number neutrophils lymphocytesfrom automatic hematology analyzer. Correlation variables performedusing Spearman test.Results: median IL-17, CPR, 363.55 (11.4-1695.80)pg/mL, 13.25 (0.43-53.87) mg/L, 12.00 (2.26–48.5), respectively. Spearmancorrelation test p = 0.019, r 0.37, p= 0.425, 0.13.Conclusion: There weak positive inseptic patients. no